Antibiotics and Antibiotic Resistance

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چکیده

A AAC(60)-Ib-cr, 185 ACHN-975 clinical studies, 163–164 medicinal chemistry, 166 structure, 162 AcrAB-TolC, 180 AcrD, 236 AdeRS, 257 AFN-1252 mechanism of action, 148, 153 resistance, 153 structure, 149 AIM-1, 74 Amicoumacin A, 222 Amikacin indications, 240 structure, 230 synthesis, 4 Aminoglycosides. See also specific drugs historical perspective, 229–230 indications, 239–241 mechanism of action, 232 novel drugs, 237 pharmacodynamics, 238–239 pharmacokinetics, 238–239 resistance mechanisms aminoglycoside-modifying enzymes acetyltransferases, 233–235 nucleotidyltransferases, 235 phosphotransferases, 235 efflux-mediated resistance, 236 molecular epidemiology, 236–237 overview, 17, 233 ribosomal RNA modifications, 235–236 spectrum of activity, 230–232 structures, 230 targets, 17 Amoxicillin, structure, 27 AmpC, 74 Ampicillin, structure, 26 Antibiotic resistance dating challenges, 9 experimental evidence for old resistance, 11–12 phylogenetics, 11 sequencing techniques, 9–10 technology impact, 10–11 Antibiotic restriction, guidelines, 5 Antifolates. See also specific drugs novel compounds, 378–379 overview, 373–374 resistance mechanisms sulfamethoxazole, 378 trimethoprim, 374–378 Apramycin, structure, 230 Arbekacin, 237–238 Avibactam, structure, 38 Azithromycin resistance, 291, 295 structure, 272 Aztreonam, structure, 36

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تاریخ انتشار 2016